![]() There is risk of over- and undertreating patients with ambiguous melanocytic tumors because it is implicitly not known which lesion is benign and which is malignant. There is a paucity of literature on these lesions and their management. 11 Atypical melanocytic proliferations often involve expert consultation and require management based on a review of the clinical situation and favored opinions by pathologists. ![]() A lack of standardized diagnostic terminology makes it challenging to gauge clinical behavior and guide treatment. When evaluating an atypical melanocytic proliferation, pathologists may not be able to establish a definitive diagnosis and/or disagree with each other on the nature of the tumor. 1– 10 These lesions are often referred to as atypical melanocytic proliferations. Most histological diagnoses involving melanocytic lesions can be made with a high level of certainty, reproducibility, and agreement among dermatopathologists however, there exists a subset of melanocytic neoplasms that can be difficult to classify as benign or malignant based on conventional microscopic analysis. Early detection of melanoma is key from a patient prognosis standpoint, and as such the authors rely on an accurate histopathological assessment.
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